Suspension
| Front | |
| 4×2 | Independent twin I-beam (narrow front track) with coil springs, shock absorbers, stabilizer bar (F-250/F-350) |
| 4×4 | Mono beam (narrow front track) with coil springs, shock absorbers, stabilizer bar (F-250/F-350)
Mono beam (wide front track) with coil springs, shock absorbers, stabilizer bar (F-450) |
| Rear | |
| 4×2 | Live axle with leaf springs, staggered shock absorbers and stabilizer bar; stabilizer bar standard on DRW models and available with camper package SRW pickups |
| 4×4 | Live axle with leaf springs, staggered shock absorbers; stabilizer bar standard on DRW models and available with camper package and camper/snowplow combination package SRW pickups (snowplow package does not come with a rear stabilizer bar) |
| STEERING | |
| Type | Power-assist |
| Overall ratio | 20.49:1 (F-250/F-350 4×2); 20.41:1 (F-250/F-350 4×4); 20.41:1 average (F-450) |
| BRAKES | |
| Type | Four-wheel vented disc, ABS (standard) |
| Front | 14.29-in. discs |
| Rear | 14.29-in. discs |
| Assist type | Vacuum (F-250/F-350 SRW)/hydroboost (F-350 DRW/F-450) |
| WHEELS AND TIRES | |
| Base wheel and tire | Steel or aluminum; 17-in., 18-in. or 20-in. (F-250/F-350); 17-in. (F-350 DRW/F-450) |
| Largest wheel available | LT275/65R20E All-Terrain OWL (outlined white letter) |
Front Springs
| Part Number | Alt Part Number | Spring Code | Spring Weight |
| 5C3Z-5310-AA | 5C34-5310-AMD | A | 7000lbs |
| 5C3Z-5310-BA | 5C34-5310-ALD | B | 6500lbs |
| 5C3Z-5310-CA | F81A-5310-AHD | C | 6000lbs |
| 5C3Z-5310-DA | F81A-5310-AGD | D | 5600lbs |
| 5C3Z-5310-EA | F81A-5310-AFD | T | 5200lbs |
| 5C3Z-5310-FA | F81A-5310-AED | V | 4800lbs |
| 5C3Z-5310-GA | F81A-5310-ADD | W | 4400lbs |
| 5C3Z-5310-HA | F81A-5310-ACD | X | 4000lbs |